PLATELETS AND THROMBOPOIESIS Anucleate platelets generate progeny
نویسندگان
چکیده
1Program in Human Molecular Biology and Genetics and 2Department of Surgery, University of Utah, Salt Lake City; 3Department of Nanoscale Imaging of Cellular Dynamics, Courant Research Centre Nano-Spectroscopy and X-Ray Imaging, University of Göttingen, Göttingen, Germany; 4Department of Physics and Harvard School of Engineering and Applied Sciences, Harvard University, Cambridge, MA; 5Division of Haematology/Oncology, Program in Cell Biology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON; 6ARUP Laboratories and 7Department of Pathology, University of Utah, Salt Lake City; 8Institut für Immunologie und Transfusionsmedizin, University of Greifswald, Greifswald, Germany; and 9Department of Internal Medicine, University of Utah, Salt Lake City
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Cytoskeletal mechanics of proplatelet maturation and platelet release
Megakaryocytes generate platelets by remodeling their cytoplasm into long proplatelet extensions, which serve as assembly lines for platelet production. Although the mechanics of proplatelet elongation have been studied, the terminal steps of proplatelet maturation and platelet release remain poorly understood. To elucidate this process, released proplatelets were isolated, and their conversion...
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